Endocrine Abstracts

Available evidence suggests that Syzygium spp ethyl acetate extract solubles (EAS) contain triterpene constituents; oleanolic acid (OA), ursolic acid (UA) and methyl maslinate with hypoglycaemic properties. The effects of maslinic acid (MA) on blood glucose in type 1 diabetes mellitus are, however, unclear. Accordingly, we evaluated anti-hyperglycaemic effects of MA in streptozotocin (STZ)-induced diabetic rats, an experimental model for type 1 diabetes. Extraction and fractio...

Chloroquine (CHQ) the most frequently used drug for falciparum malaria in sub-Saharan Africa countries evokes adverse effects on glucose homeostasis and kidney function in African children. The complications can partly be ascribed to transiently high plasma CHQ concentrations following oral administration and/or malaria parasites. We have, however, reported that topical application of the pectin CHQ matrix patch releases CHQ into the bloodstream. Accordingly, the curr...

Available evidence suggests that Syzygium spp ethyl acetate solubles (EAS) contain triterpene mixtures (oleanolic/ursolic acid and methyl maslinate/methyl corosolate) with hypoglycaemic properties in streptozotocin (STZ)-induced diabetic rats. Accordingly, maslinic acid (MA) was isolated from S. aromaticum. Air-dried powdered flower buds of S. aromaticum were sequentially extracted thrice at 24 h intervals with 3 litres on each occasion of hexane, dichloromethane, ethyl acetat...